Contents Foreword Introduction 1 Scope 2 Normative References 3 Terms and definitions 4 General principles — Step-wise approach 5 Pretest considerations 6 Irritation tests 7 Delayed hypersensitivity tests 8 Key factors in interpretation of test results Annex A (Normative) Preparation of materials for irritation/sensitization testing A.1 General A.2 Materials for direct-contact exposure A.3 Extracts of test materials A.4 Solvents A.5 Sterile test materials Annex B (Informative) Additional irritation tests B.1 General B.2 Intracutaneous (intradermal) reactivity test B.3 Ocular irritation test B.4 oral mucosa irritation test B.5 Penile irritation test B.6 Rectal irritation test B.7 Vaginal irritation test Annex C (Informative) Background information C.1 Background information on irritation tests C.2 Background information on sensitization tests for delayed hypersensitivity Bibliography |